The Study: Rationale and Development of HR23+

The HR23+ formula was developed based on extensive scientific research and clinical trials. Its effectiveness is primarily driven by the carefully selected combinations of ingredients that have been shown in studies to be highly beneficial for preventing hair loss and stimulating hair growth.

Here, we explain the scientific rationale behind the HR23+ supplement, supported by findings from various studies and trials. This approach is what has made HR23+ a highly effective non-medical hair health supplements available today.

Key additive: Saw Palmetto



Saw palmetto has been studied in clinical trials for hair loss prevention, particularly for androgenetic alopecia (AGA), the most common form of hair loss. Saw palmetto is a plant extract that is believed to act as a 5-alpha-reductase inhibitor, similar to medications like finasteride. By inhibiting the conversion of testosterone to dihydrotestosterone (DHT), which is implicated in hair follicle miniaturisation, it may help slow or prevent hair loss.

Combination Therapies with Saw Palmetto: While saw palmetto can help reduce hair loss, it has been shown to be significantly more effective when paired with other essential ingredients. Several combinations of saw palmetto with other ingredients have been studied or used to enhance its efficacy in hair loss prevention, especially for androgenetic alopecia.

Saw Palmetto + Biotin

Biotin is a B-vitamin essential for keratin production, the primary protein in hair. While biotin deficiency is rare, its supplementation is often included in hair-loss regimens to support hair strength and growth. Combination products have shown benefits in improving hair texture, thickness, and reducing shedding.

Example Study: A 2015 study on a nutraceutical containing saw palmetto, biotin, and other nutrients reported improved hair density and quality after 12 weeks.

Saw Palmetto + Pumpkin Seed

Pumpkin seed oil contains phytosterols and other compounds that inhibit DHT production, similar to saw palmetto. It also has anti-inflammatory properties that improve scalp health. A 2014 randomized trial found that pumpkin seed oil alone improved hair growth by 40% in men with AGA over 24 weeks. Combined with saw palmetto, it may have synergistic effects.

Saw Palmetto + Zinc

Zinc plays a role in hair follicle recovery and reduces DHT production. Zinc deficiency is linked to hair thinning, and its supplementation (combined with saw palmetto) has shown some improvement in hair density and strength.

Saw Palmetto + Green Tea Extract (EGCG)

Green tea extract contains epigallocatechin gallate (EGCG), which has been shown to inhibit DHT activity and stimulate hair growth. This combination leverages dual mechanisms: reducing DHT and promoting anagen-phase follicle activity.

Saw Palmetto + Nettle Leaf

Rationale: Nettle root is another natural DHT inhibitor. It also contains silica, which strengthens hair shafts. Anecdotal evidence suggests that combining these two can amplify DHT-blocking effects, though more research is needed.


Key additives: Inositol and Choline

Choline and Inositol Combination Therapies: Choline and inositol are both B-vitamin-like compounds often used in combination for their synergistic effects on cellular health, fat metabolism, and nervous system function. While they are not directly marketed as treatments for hair loss, they have shown to contribute to improved hair health and potentially reduce hair shedding through their role in lipid metabolism and scalp health.

Synergistic Effects: Choline and inositol together support the synthesis of lecithin, a compound that plays a role in lipid transport and utilisation in the body. Healthy lipid metabolism can positively affect scalp sebum balance, promoting healthier hair growth. Both compounds contribute to stress reduction and overall metabolic balance, which are indirectly beneficial for hair health.

Research on choline and inositol specifically for hair loss is limited, but the following insights are relevant:

1. Supporting Liver and Hormonal Health:
• Imbalances in hormone metabolism, especially involving androgens (e.g., DHT), are a primary cause of androgenetic alopecia. Choline and inositol may support liver detoxification and hormone regulation, indirectly reducing the impact of DHT on hair follicles.
2. Stress and Scalp Health:
• Chronic stress can lead to telogen effluvium (a form of hair shedding). Both choline and inositol have calming effects on the nervous system and may reduce stress-related hair loss.
3. Anecdotal and Supplement-Based Evidence:
• Choline and inositol are commonly included in multivitamin complexes for hair, skin, and nails, suggesting their supportive role in general hair health.
• Some anecdotal evidence suggests improvements in hair texture and reduced shedding when these are taken regularly, especially in individuals with metabolic or hormonal imbalances.

Key additive: Folate (Folic Acid)



Combination Therapies with Folic Acid: Folate and specific metals (minerals) play essential roles in hair health, primarily by supporting cell division, DNA synthesis, and the production of keratin, the main structural protein in hair. Here are key combinations of folate (vitamin B9) with various metals that have been studied or proposed for improving hair health and preventing hair loss:

Folate + Zinc

Folate supports rapid cell division and DNA synthesis, essential for active hair follicle growth during the anagen phase. Zinc deficiency is linked to alopecia areata and other hair disorders. Folate enhances zinc’s effectiveness in promoting hair regrowth. This combination is particularly beneficial for individuals with poor scalp health or autoimmune-related hair loss.

Folate + Copper

Copper is involved in the production of melanin, the pigment responsible for hair colour, and plays a role in collagen formation for healthy hair structure. Folate ensures proper cell turnover and supports copper’s enzymatic functions in the scalp. Folate and copper together may improve hair pigmentation and delay premature greying. They also support scalp blood circulation and strengthen hair shafts.

Folate + Magnesium

Magnesium helps regulate calcium levels in the body and promotes healthy hair follicles by reducing scalp calcification, which can impede hair growth. Folate boosts the metabolic activities required for hair follicle repair and growth. Magnesium deficiency has been linked to increased hair shedding and brittle hair. Paired with folate, magnesium improves overall scalp and follicle health. This combination also supports stress management, which indirectly reduces hair loss.

Key additive: Ginkgo Biloba

Ginkgo biloba is a herbal additive known for its ability to improve blood circulation, enhance oxygen delivery, and act as an antioxidant. These properties make it a potentially beneficial adjunct in hair loss treatments, particularly for improving scalp health and stimulating dormant hair follicles. While it is not a direct treatment for conditions like androgenetic alopecia (which involves hormonal factors like DHT), it has shown to complement other therapies.

Combination Therapies with Folic Acid: Combination therapies involving folic acid have shown promise in improving hair health, especially when paired with other essential nutrients. Folic acid, a B-vitamin, plays a key role in cell growth and regeneration, which is crucial for healthy hair follicles. Studies suggest that combining folic acid with biotin, zinc, vitamin D, and copper can support both hair strength and growth by addressing nutritional deficiencies that contribute to hair thinning and loss.

Ginkgo Biloba + Biotin

Biotin (Vitamin B7) supports keratin production, which is critical for hair structure and strength. Ginkgo improves blood flow to the scalp, ensuring optimal delivery of nutrients like biotin to the hair follicles. A study in 2015 showed that the combination of ginkgo biloba and biotin can improve hair strength, reduce breakage, and support regrowth, particularly in cases of diffuse thinning.

Ginkgo Biloba + Saw Palmetto

Saw palmetto blocks the enzyme 5-alpha reductase, reducing the production of dihydrotestosterone (DHT), which causes hair follicle miniaturisation in androgenetic alopecia. Ginkgo enhances scalp blood flow, improving the efficacy of DHT-blocking ingredients like saw palmetto. Together, they address the hormonal and circulatory aspects of hair loss. This combination is used in order to target male and female pattern baldness.

Ginkgo Biloba + Zinc + Selenium

Zinc supports hair follicle recovery, reduces inflammation, and combats dandruff. Ginkgo enhances the bioavailability of these minerals by improving blood flow and nutrient absorption. This key combination is particularly effective for hair thinning caused by poor scalp health or underlying thyroid issues.

Key additive: Horsetail

Horsetail (Equisetum arvense) is gaining attention in the realm of hair health due to its high silica content, which is known to strengthen hair strands, enhance hair texture, and promote overall scalp health. Some scientific studies have specifically linked horsetail to hair regrowth, and it has been widely used in traditional medicine and modern hair care formulations for improving hair vitality. The resources Medicinenet and FullyVital provide insights into both the traditional uses and modern applications of horsetail for maintaining and enhancing hair health.

Combination Therapies with Horsetail: Combination therapies that include horsetail extract are gaining popularity for supporting hair health. Horsetail is rich in silica, a mineral that strengthens hair strands and promotes collagen production, contributing to healthier hair growth. When combined with other hair health treatments such as biotin, vitamins, or minoxidil, horsetail can enhance the overall effectiveness by improving scalp circulation, providing essential nutrients, and preventing hair breakage. This natural supplement, when paired with other therapeutic ingredients, offers a comprehensive approach to addressing hair thinning and promoting fuller, more resilient hair.

Horsetail + Ginkgo Biloba

Ginkgo biloba improves scalp blood circulation, ensuring nutrients from horsetail and other supplements reach the follicles. Horsetail strengthens the hair that grows as a result of improved follicle nourishment. This key combination as shown to help stimulate dormant follicles, promote regrowth, and combat thinning strands by increasing nutrient delivery.

Horsetail + MSM (Methylsulfonylmethane)

MSM provides sulfur, a key component in keratin, which strengthens hair strands. Horsetail complements MSM by enhancing nutrient delivery to hair follicles and supporting keratin synthesis. This considered combination of Horsetail and MSM stimulate stronger, faster-growing hair, while reducing hair shedding and brittleness. Studies have also shown horsetail to work efficiently with potent extracts like saw palmetto, nettle leaf, and pumpkin seed – all of which are used in the HR23+ formula.

Summary

Various studies suggest that combining specific ingredients within a supplement for hair health is crucial for maximising effectiveness by targeting various aspects of hair growth and strength. Ingredients like biotin, folic acid, zinc, and vitamin D work synergistically to address deficiencies that contribute to hair thinning. For instance, folic acid promotes healthy cell growth, while biotin enhances keratin production, essential for hair structure. Zinc plays a role in regulating the scalp’s oil production, and vitamin D supports follicle activation.

Research suggests that multi-nutrient formulations are far more effective than single-ingredient supplements, as they provide comprehensive support, addressing both structural and environmental factors that affect hair health. This approach not only boosts hair growth but also enhances overall hair strength, density, and shine.

HR23+ is a meticulously crafted, science-backed formula designed to address the root causes of hair loss. Supported by extensive research and studies, HR23+ has consistently proven to be a highly effective solution for both men and women facing the challenging impact of hair loss.